Synthesis and Characterization of Compounds Related to Lisinopril.
نویسندگان
چکیده
Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterization, and control of this impurity. This paper also describes the synthesis and characterization of three other impurities listed in the European Pharmacopoeia 8.4 (Impurity C, D, and F).
منابع مشابه
Preparation of Combination Tablet Containing Lisinopril (10mg)/Hydrochlorothiazide (12.5mg): Characterization and Stability studies
In modern clinical practice, combination fixed - dose tablets have become a baseline foreffective therapy in many clinical conditions. The Hydrochlorothiazide (Hctz) (12.5mg) /Lisinopril (Lis) (10 mg) tablet is a combination drug for treatment of hypertension. In thisstudy, the tablets were prepared by wet granulation method and characterized in terms of weightvariation, hardness, friability, d...
متن کاملNew Benzimidazoles Derivatives: Synthesis, Characterization and Antifungal Activities
One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with pharmaceutical activity. Thus, a novel series of the derivatives of benzimidazole were synthesized and the structures of all the synthesized compounds have been confirmed by IR, 1 H- and 13C-NMR, Mass Spectroscopy and elemental analysis. The title compounds have been evaluated for antifu...
متن کاملSynthesis, Spectral Characterization and Analgesic Activity of 2-Methylthio-1, 4-Dihydropyrimidines
A series of 2-methylthio-1,4-dihydropyrimidine derivatives (II) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (I) with methyl iodide in the presence of pyridine. Their structures were confirmed by elemental analysis, IR and 1H NMR spectra. The compounds were tested for analgesic activity by acetic acid induced writhing method. Compounds IIh, IIe, IIk and IIl sho...
متن کاملSynthesis, Spectral Characterization and Analgesic Activity of 2-Methylthio-1, 4-Dihydropyrimidines
A series of 2-methylthio-1,4-dihydropyrimidine derivatives (II) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (I) with methyl iodide in the presence of pyridine. Their structures were confirmed by elemental analysis, IR and 1H NMR spectra. The compounds were tested for analgesic activity by acetic acid induced writhing method. Compounds IIh, IIe, IIk and IIl sho...
متن کاملSynthesis and Characterization of Silver/Alumina Powders
In this research, synthesis and characterization of silver/alumina composite powders was investigated. This kind of metal/ceramic composite powders is used for fabrication of cutting tools inserts. The role of silver is toughening the final product. The powders were synthesized via co-precipitation method. The composition of the synthesized powders was Ag/80% wt 〖Al〗_2 O_3. Silver nitrate, alum...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Scientia pharmaceutica
دوره 84 2 شماره
صفحات -
تاریخ انتشار 2016